Julie Carcaud


Carcaud, J., M. Giurfa & J.-C. Sandoz (2018) Differential Processing by Two Olfactory Subsystems in the Honeybee Brain. Neuroscience, 374, 33-48. 10.1016/j.neuroscience.2018.01.029.

Carcaud, J., M. Giurfa & J. C. Sandoz (2016) Parallel Olfactory Processing in the Honey Bee Brain: Odor Learning and Generalization under Selective Lesion of a Projection Neuron Tract. Frontiers in Integrative Neuroscience, 9. 10.3389/fnint.2015.00075.

Devaud, J. M., T. Papouin, J. Carcaud, J. C. Sandoz, B. Grunewald & M. Giurfa (2015) Neural substrate for higher-order learning in an insect: Mushroom bodies are necessary for configural discriminations. Proceedings of the National Academy of Sciences of the United States of America, 112, E5854-E5862.

Carcaud, J., M. Giurfa & J.-C. Sandoz (2015) Differential Combinatorial Coding of Pheromones in Two Olfactory Subsystems of the Honey Bee Brain. Journal of Neuroscience, 35, 4157-4167.

Roussel, E., J. Carcaud, M. Combe, M. Giurfa & J.-C. Sandoz (2014) Olfactory Coding in the Honeybee Lateral Horn. Current Biology, 24, 561-567.

Junca, P., J. Carcaud, S. Moulin, L. Garnery & J.-C. Sandoz (2014) Genotypic Influence on Aversive Conditioning in Honeybees, Using a Novel Thermal Reinforcement Procedure. Plos One, 9.

Claude Wicker-Thomas

The pheromonal communication in the drosophila

Phone. 01 69 82 37 08
Fax 33 1 69 82 37 36

Research Topics

In  Drosophila, a courtship precedes the coupling; pheromones situated on the cuticle have a very important role in this behavior of court and would play an important role in the speciation. Two twin species, Drosophila melanogaster and D. simulans , have very different pheromonal systems, with the presence of a sexual pheromonal dimorphisme to only the first species. We characterized the main genes of pheromones’ biosynthesis to these two species. We propose the fine study of their regulation by using at the same time biochemical methods (chromatography in gas phase), genetics (RNAi), behavioral (court) and molecular (level of genes expression, the analysis of the promoters) to study the evolution of this regulation. This study should allow to understand better the place of pheromones in the reproductive success, the role of hormones (ecdysone, young hormone), neurotransmitters (dopamine, serotonin) in their control and the evolution of this control.


Fumey, J. & C. Wicker-Thomas (2017) Mutations at the Darkener of Apricot locus modulate pheromone production and sex behavior in Drosophila melanogaster. Journal of Insect Physiology, 98, 182-187. 10.1016/j.jinsphys.2017.01.005.

Denis, B., G. Claisse, A. Le Rouzic, C. Wicker-Thomas, G. Lepennetier & D. Joly (2017) Male accessory gland proteins affect differentially female sexual receptivity and remating in closely related Drosophila species. Journal of Insect Physiology, 99, 67-77. 10.1016/j.jinsphys.2017.03.008.

Wicker-Thomas, C., Garrido D., Bontonou, G., Napal L., Mazuras N., Denis, B., Rubin T., Parvy J.P., Montagne J. 2015 Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. J. Lipid Res. 56, 2094-2101.

Denis, B., Le Rouzic A.,Wicker-Thomas, C. 2015 Hydorcarbon patterns and mating behaviour  in populations of Drosophila yakuba. Insects, 6, 897-911.

Bontonou, G.,Shaik, H.A., Denis, B., Wicker-Thomas, C. 2015 Acp70A regulates Drosophila pheromones through juvenile hormone induction. Insect Biochem. Molec. Biol. 56, 36-49.

Bontonou, G.,Wicker-Thomas, C. 2014 Sexual communication in the Drosophila genus. Insects, 5, 439-458.

Bontonou G., Denis B., Wicker-Thomas C. 2013 Interaction between temperature and male pheromone in sexual isolation in Drosophila melanogaster. J. Evol. Biol., 26, 2008-2020.

Qiu Y., Tittiger C., Wicker-Thomas C., Le Goff G., Younga S., Wajnberg E., Fricaux T., Taquet N., Blomquist G.J., Feyereisen R. 2012 An insect-specific P450 oxidative decarbonylase for cuticular hydrocarbon biosynthesis. Proc. Natl. Acad. Sci. USA 109, 14858-14863.

Ruiz M., Wicker-Thomas C., Sanchez D., Ganfornina M. D. 2012 Grasshopper lazarillo, a GPI-anchored lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homologue NLaz. Insect Biochem. Molec. Biol. 42, 776-789.

Bontonou G., Denis B., Wicker-Thomas C. 2012 Male pheromone polymorphism and reproductive isolation in populations of Drosophila simulans. Ecology and Evolution 2, 2527-2536.

Parvy J.P.,  Napal L., Rubin T., Poidevin M., Perrin L., Wicker-Thomas C., Montagne J. 2012 Drosophila acetyl-CoA-carboxylase sustains a fatty acid-dependent remote signal to waterproof the respiratory system. PLOS Genet. 8,e1002925.

Veltsos P., Wicker-Thomas C., Butlin R., Hoikkala A., & Ritchie M. G. 2012 Sexual selection on song and cuticular hydrocarbons in two distinct populations of Drosophila montana. Ecology and Evolution 2, 80-94.

Wicker-Thomas C. 2012 Signaux chimiques, adaptation et spéciation (Chapitre 23). In« ODORAT et GOUT : de la neurobiologie des sens chimiques aux applications agronomiques, industrielles et médicales », Eds  R. Salesse & R. Gervais, Editions QAE, Versailles, 311-320.

Keays M. C., Barker D., Wicker-Thomas C., Ritchie M. G. 2011 Signatures of selection and sex-specific alternative splicing during the evolution of the Drosophila desaturase gene family. Mol. Ecol. 20, 3617-3630.

Wicker-Thomas C. 2011 Evolution of insect pheromones and their role in reproductive isolation and speciation. Ann. Soc. Entomol. Fr. 47, 55-62.

Arienti M., Antony A., Wicker-Thomas C., Delbecque J. P., Jallon J. M. 2010 Ontogeny of D. melanogaster female sex-appeal and cuticular hydrocarbons. Integr. Zool. 5, 272-282.

Wicker-Thomas C., Chertemps T. 2010 Molecular biology and genetics of hydrocarbon production. (Chapter 4). In “Insect hydrocarbons : biology, chemistry and chemical ecology ”, Eds G. J. Blomquist and A. G. Bagnères , Cambridge University Press,  53-74.

Bagnères, A. G., Wicker-Thomas C. 2010 Chemical taxonomy with hydrocarbons. (Chapter 7). In “Insect hydrocarbons : biology, chemistry and chemical ecology ”, Eds G. J. Blomquist and A. G. Bagnères , Cambridge University Press,  121-162.

Hefetz, A., Wicker-Thomas C.,  Bagnères, A. G. 2010 New areas of research on insect hydrocarbons and conclusion. (Chapter 20). In “Insect hydrocarbons : biology, chemistry and chemical ecology ”, Eds G. J. Blomquist and A. G. Bagnères ,Cambridge University Press,  477-485.

Gleason J. M., James R. A., Wicker-Thomas C., Ritchie M. G. 2009 Identification of quantitative trait loci function through analysis of multiple cuticular hydrocarbons differing between Drosophila simulans and D. sechellia females. Heredity 103, 416-424.

Wicker-Thomas C, Guenachi I, Keita Y. F. 2009 Contribution of oenocytes and pheromones to courtship behaviour in Drosophila. BMC Biochem. Aug 11;10:21.

Legendre A., Miao X. X., Da Lage J. L., Wicker-Thomas C. 2008 Evolution of a desaturase involved in female cuticular hydrocarbon biosynthesis and courtship behaviour in Drosophila. Insect Biochem. Molec. Biol. 38, 244-253.

Wicker-Thomas C., Hamann M. 2008 Interaction of dopamine, female pheromones, locomotion and sex behaviour in Drosophila melanogaster. J. Insect Physiol.. 54, 1423-1431.

Chertemps T., Duportets L., Labeur C., Ueda R., Takahashi K., Saigo K., Wicker-Thomas C. 2007 A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA.104, 4273-4278.

Wicker-Thomas C. 2007 Review. Pheromonal communication involved in courtship behaviour in Diptera. J. Insect Physiol. 53, 1089-1100.

Chertemps T., Duportets L., Labeur C., Ueyama M., Wicker-Thomas C. 2006 A female specific desaturase gene responsible for diene hydrocarbon biosynthesis and courtship behavior in D. melanogaster. Insect Mol. Biol. 15, 465-473.

Ueyama M., Chertemps T., Labeur C., Wicker-Thomas C. 2005 Mutations in the desat1 gene reduces the production of courtship stimulatory pheromones through a marked effect on fatty acids in Drosophila melanogaster. Insect Biochem. Molec. Biol. 35, 911-920.

Chertemps T., Duportets L., Labeur C., Wicker-Thomas C. 2005 A new elongase selectively expressed in Drosophila male reproductive system. Biochem Biophys Res Commun. 333, 1066-1072.

Rouault J. D., Marican C., Wicker-Thomas C., Jallon J. M. 2004  Relations between cuticular hydrocarbon (HC) polymorphism, resistance against desiccation and breeding temperature: a model for HC evolution in D. melanogaster and D. simulans. Genetica 120, 195-212.

Jallon J. M., Wicker-Thomas C. 2003 Genetic studies on pheromone production in Drosophila. (Chapter 9). In “Insect Pheromone Biochemistry and Molecular Biology. Part 1. Biochemistry and Molecular Biology of pheromone production”, Eds G. J. Blomquist and G. Vogt , pp253-281.

Labeur C., Dallerac R., Wicker-Thomas C. 2002 Involvement of desat1 gene in the control of Drosophila melanogaster pheromone biosynthesis. Genetica 114, 269-274.

Wicker-Thomas C., Jallon J. M. 2001 Control of female pheromones in Drosophila melanogaster by homeotic genes. Genet. Res.78, 235-242.

Wicker-Thomas C., Jallon J. M.  2000  Role of Enhancer of zeste on the production of Drosophila melanogaster pheromonal hydrocarbons. Naturwissenschaften. 87, 76-79.

Dallerac R., Labeur C., Jallon J. M., Knipple D. C., Roelofs W.L., Wicker-Thomas C. 2000 A  D9 desaturase gene with a different substrate specificity is responsible for the cuticular diene hydrocarbon polymorphism in Drosophila  melanogaster. Proc. Natl. Acad. Sci. USA 97, 9449-9454.

Coyne J. A., Wicker-Thomas C., Jallon J. M.  1999  A gene responsible for a cuticular hydrocarbon  polymorphism in Drosophila melanogaster. Genet. Res., 73, 189-203.

Wicker-Thomas C., Henriet C., Dallerac R.  1997  Partial characterization of a fatty acid desaturase gene in Drosophila melanogaster. Insect Biochem. Molec. Biol. 27, 963-972.

Wicker C., Jallon J. M.  1995  Hormonal control of sex pheromone biosynthesis in Drosophila melanogaster. J. Insect Physiol 41, 65-70.

Wicker C., Jallon J. M.  1995  Influence of ovary and ecdysteroids on pheromone biosynthesis in Drosophila melanogaster (Diptera: Drosophilidae). Eur. J. Entomol. 92, 197-202.

El Messoussi S., Wicker C., Arienti M., Carlson D.A., Jallon J. M.  1994  Hydrocarbons in species recognition in insects.  In « Identification and characterization of pest organisms », Eds D. Hawskworth, CABI Press, London, pp. 277-287.

Dominique, Joly

Researcher Director CNRS
Doctor of sciences, 1989, HDR 2001, University Paris-Sud

Phone: 33 1 69 82 37 34
Fax: 33 1 69 82 37 36

Research Topics
Four thematic axes were developed these last years:

1- The first axe is centered on the study of the sexual postcopulatoire selection and the adaptations which influence the descendants’ paternity. The originality of my contribution is to document the diversity of these adaptations and to analyze the role of the sexual conflict in the evolution of the characters, discriminating between the male effects and the effects females from a point of view behavioral, morphological, biochemical and genetic. The accent was put these last years on the effect of the seminal fluid on the reproductive strategies of females.
Coll Claude Wicker-Thomas, Béatrice Denis, Gaëlle Claisse, financing ANR and FRB.

2- The second axe concerns the analysis of the expression genic changes  as source of phenotypic variations intra- and interspecific. The use of broadband analysis tools  of the transcriptome allows to quantify these changes on the scale of the genome. We try to determine how the deregulated genes position in the networks of genic regulation and if these ways are specific or not of various studied models.
Coll Catherine Montchamp-Moreau, David Ogereau and François Wurmser’s thesis, financing by CNRS-INEE, ANR and IDEEV.

3-The third axe concerns the study of the social learning  as generator of biodiversity. The behavior modifications are possible during the life of the individuals by the observation or the interaction with other individuals. We try to understand the relations enter social and individual learning, determine the genetic bases of the social learning, study the dynamics of this learning in the time and in the space, and characterize the stability of these interactions during the generations.
Coll F. Mery, and mister . Battesti’s thesis, financing by ERC, ANR.

4- Finally the fourth axe, more recent, sends the questions of natural pesticides impact on the reproduction and the sexual selection at non-target individuals. This approach was rarely approached on the literature and demonstrates the potentially important effects on the survival of wild populations.

Mots-clés: Evolution des stratégies de reproduction, sélection sexuelle, compétition spermatique, choix cryptique, stress environnementaux (température, pesticides), génomique et protéomique,

Keywords: Evolution of reproduction strategies, sexual selection, spermatic competition, cryptic choice, environmental stress’ (temperature, pesticides), genomics and protéomique,


Deputy director EGCE

Deputy director Scientist Ecology and Environment CNRS INEE institute

Coordinator GDR3692 Environmental Genomics
Coordinator RTP Epigenetic in ecology and evolution

Mobile phone: 33 6 78 13 71 71
Phone: 33 1 44 96 40 53
Fax: 33 1 44 96 45 11


OULHACI C.M., DENIS B., KILANI-MORAKCHI S., SANDOZ J-C., KAISER-ARNAUD L., JOLY D. & ARIBI N. 2018 Azadirachtin effects on mating success, gametic abnormalities and progeny survival in Drosophila melanogaster (Diptera). Pest Management Science 74:174-180. pdf

ARIBI N., OULHACI C.M., DENIS B., KILANI-MORAKCHI S., SANDOZ J-C., KAISER-ARNAUD L. & JOLY D. 2017 Azadirachtin impact on mate choice, female sexual receptivity and male activity in Drosophila melanogaster (Diptera: Drosophilidae). Pesticide Biochemistry and Physiology 143:95-101. pdf

JOLY D. & THIEBAULT S. Des dispositifs scientifiques pour étudier l’adaptation du vivant au changement global, dans « Adaptation au changement climatique », Ouvrage collectif, CNRS – Comité 21, responsables scientifiques A. Euzen, B. Laville et S. Thiébault. Versions française et anglaise. pdf

GRUNAU C. & JOLY D., L’héritabilité dans un monde changeant : épigénétique et changement climatique, dans « Adaptation au changement climatique », Ouvrage collectif, CNRS – Comité 21. Version s française et anglaise.

DENIS B.*, CLAISSE G.*, LE ROUZIC A., WICKER-THOMAS C., LEPENNETIER G. & JOLY D. 2017 Male accessory gland proteins affect differentially female sexual receptivity and remating in closely related Drosophila species. Journal of Insect Physiology 99:67-77. *Ont également contribué  pdf

JOLY D., FAURE D. 2017 Chapitre 10. Le décryptage haut débit du vivant; dans « Les Big Data à découvert », Bouzeghoub M. et Mosseri R. (eds), CNRS Editions, pp 222-223.

JOLY D. 2017 membre du comité editorial, « Les Big Data à découvert », Bouzeghoub M. et Mosseri R. (eds), CNRS Editions, 350 pages.

FAURE D., JOLY D. (eds) 2016 La génomique environnementale : la révolution du séquençage à haut debit, ISTE Editions, Collection Ecologie dirigée par Françoise Gaill, 150 pages.

FAURE D., JOLY D. (eds) 2016 Insight on Environmental Genomics: the high-throughput sequencing revolution, ISTE Editions, Series Editor Gaill F., 153 pages.

ARIBI N., OULHACI C., BOULAHBEL B., JOLY D., DENIS B. & KILANI-MORAKCHI S. 2015. Negative effects of Azadirachtin (Neem-Azal) on non cibled species Drosophila melanogaster (Diptera): delayed effects on reproduction. Toxicology Letters, 238 (2): S103. pdf

JOLY D., FAURE D, SALAMITOU S. 2015 Empreinte du vivant : l’ADN de l’environnement. Edition du cherche midi. Paris. 192 pp. *Prix Veolia de l’environnement.

MOUQUET N., LAGADEUC Y., DEVICTOR V., DOYEN L., DUPUTIÉ A., EVEILLARD D., FAURE D., GARNIER E., GIMENEZ O., HUNEMAN P., JABOT F., JARNE P., JOLY D.., JULLIARD R., KÉFI S., J. KERGOAT G., LAVOREL S., LE GALL L., MESLIN L., MORAND S., MORIN X., MORLON H., PINAY G., PRADEL R., SCHURR F.M., THUILLER W. & LOREAU M. 2015 Improving predictive ecology in a changing world. Journal of Applied Ecology 52:1293-1310. pdf

PORCELLI D., BUTLIN R.K., GASTON K.J., JOLY D. & SNOOK R.R.. 2015 The environmental genomics of thermal adaptation. Heredity 114: 502-514. pdf

JOLY D., FAURE D. 2015 Next-generation sequencing propels environmental genomics to the front line of research. Heredity 114: 429-430. *Highlighted in The Molecular Ecologist, April, 17, 2015. pdf

JOLY D., FAURE D. (eds). 2015 Special issue : Environmental Genomics. Heredity 114:429-536. url

FAURE D., JOLY D. 2015 Next-generation sequencing as a powerful motor for advances in the biological and environmental sciences. Genetica 143(2): 129-132. pdf

FAURE D., JOLY D. (eds). 2015 Special Issue: Next-generation sequencing for Biodiversity, Taxonomy, Evolution and Ecology. Genetica 143: 129-261. url

BATTESTI M., PASQUARETTA C., MORENO C., TESEO S, JOLY D., KLENSCH E., PETIT O., SUEUR C., MERY F. 2015 Ecology of information: social transmission dynamics within groups of non-social insects. Proc Biol Sci 282(1801). pdf

BATTESTI M., MORENO C., JOLY D., MERY F. 2015 Biased social transmission in Drosophila oviposition choice. Behavioral Ecology and Sociobiology 69(1): 83-87. pdf

BEN CHEHIDA, Y., DENIS, B., CLAISSE, G., JOLY, D. 2014 Ce que l’étude des protéines du fluide séminal de drosophile nous apprend sur l’évolution de la reproduction. Medecine/Science 30:651-657 pdf

MONGET P., BOBE J., COUDERC J.-L., GUILLOMOT M., SANDRA O., DUFOUR S., JOLY D., KELLER M., PASCAL G. 2014 Evolution et reproduction. Dans “La reproduction animale et humaine”. Versailles: Editions Quae, chapitre 37, pp 687-702. Ce livre a reçu le Prix Henri Le Bars 2014 de l’Académie vétérinaire de France.

*FAURE D., *JOLY, D., Salamitou S. 2013 Prospective en Génomique Environnementale. CNRS-INEE edition. *Ont également contribué. pdf

WURMSER, F., MARY-HUARD, T., DAUDIN, J.-J., JOLY, D.,  MONTCHAMP-MOREAU C. 2013 Variation of gene expression associated with colonisation of an anthropized environment: comparison between African and European populations of Drosophila simulans. PLoS One 8, e79750. pdf

BATTESTI M., MORENO C., JOLY D., MERY F. 2012 Spread of social information and dynamics of social transmission within Drosophila groups. Current Biology 22: 1-5 pdf

WURMSER F., OGEREAU D., MARY-HUARD T., LORIOD B., JOLY D., MONTCHAMP-MOREAU C. 2011 Population transcriptomics: insights from Drosophila simulans, Drosophila sechellia and their hybrids. Genetica 39:465-477. pdf

JOLY D.,  SCHIFFER M. 2010 Coevolution of male and female reproductive structures in Drosophila. Genetica 138: 105 pdf url

JOLY D.,  SCHMITT M. (EDS). 2010 Preface Genetica 138: 1 pdf

JOLY D., CARIOU M.-L., MHLANGA-MUTANGADURA T. and LACHAISE D. 2010 Male terminalia variation in the rainforest dwelling Drosophila teissieri contrasts with the sperm pattern and species stability Genetica 138: 139 url

MCEVEY S. F., SCHIFFER M., DA LAGE J-L., DAVID J. R., LEMEUNIER F., JOLY D., CAPY P. and CARIOU M-L. 2008 Comments on the proposed conservation of usage of Drosophila Fallén, 1823 (Insecta, Diptera). Bulletin of Zoological Nomenclature 65(2): 147

ANGELARD C., MONTCHAMP-MOREAU C. and JOLY D. 2008 Female-driven mechanisms, ejaculate size and quality contribute to the lower fertility of sex-ratio distorter males in Drosophila simulans. BMC Evol. Biol. 8: 326

JOLY D., LUCK N. and DEJONGHE B. 2008 Adaptations to long sperm in Drosophila: correlated development of the sperm roller and sperm packaging. J. Exp. Zool. (Mol. Dev. Evol) 310: 167

SCHäRER L., DA LAGE J.-L. and JOLY D. 2008 Evolution of testicular architecture in the Drosophilidae: a role for sperm length. BMC Evol. Biol. 8: 143

LUCK N., DEJONGHE B., FRUCHARD S., HUGUENIN S. and JOLY D. 2007 Male and female effects on sperm precedence in the giant sperm species Drosophila bifurca. Genetica 130(3): 257

DAVID J.R., ARARIPE L.O, CHAKIR M., LEGOUT H., LEMOS B., PETAVY G., ROHMER C., JOLY D. and MORETEAU B. 2005 Male sterility at extreme temperatures: a significant but neglected phenomenon for understanding Drosophila climatic adaptations. J. Evol. Biol. 18(4): 838

LUCK, N. and JOLY, D. 2005 Sexual selection and mating advantage in the giant sperm species D. bifurca J. Insect Science 5: 10

TILL-BOTTRAUD I., JOLY D., LACHAISE D. and SNOOK R.R. 2005 Pollen and sperm heteromorphism: convergence across kingdoms? J. Evol. BIol. 18(1): 1

ATLAN A., JOLY D., CAPILLON C. and MONTCHAMP-MOREAU C. 2004 Sex-ratio distorter of Drosophila simulans reduces male productivity and sperm competition ability. J. Evol. Biol. 17(4): 744

JOLY, D., KOROL, A. and NEVO, E. 2004 Sperm size evolution in Drosophila: inter- and intraspecific analysis. Genetica 120(1): 233

ROHMER C., DAVID J.R., MORETEAU B. and JOLY D. 2004 Heat induced male sterility in Drosophila melanogaster: adaptive genetic variations among geographic populations and role of the Y chromosome. J. Exp. Biol. 207(16): 2735

JOLY, D., BRESSAC, C., JAILLARD, D., LACHAISE, D. and LEMULLOIS, M. 2003 The sperm roller: a modified testicular duct linked to giant sperm transport within the male reproductive tract. J. Struct. Biol. 142(3): 348

MALHERBE Y. and JOLY D. 2003 Sperm management in the sperm heteromorphic species, Drosophila teissieri. Drosophila Information Service 86: 53

MERY, F. and JOLY, D. 2002 Multiple mating, sperm transfer and oviposition pattern in the giant sperm species, Drosophila bifurca. J. Evol. Biol. 15(1): 49

JOLY D., BRESSAC C., JAILLARD D., LEMULLOIS M. and LACHAISE D. 2002 Ultrastructure of an additional organ between testis and seminal vesicles in Drosophila giant sperm species. In Proceedings of 9th International Symposium on Spermatology. Cape Town, G.Van der Horst, D. Franken, R. Bornman, T. Bornam & S. Dyer (eds), Monduzzi Editore 0: 13

LUCK N.,, DEJONGHE B. and JOLY D. 2002 Sexual choice and remating in a giant sperm species of Drosophila. Proceedings of 9th International Symposium on Spermatology. Cape Town, G.Van der Horst, D. Franken, , R. Bornman, T. Bornam & S. Dyer (eds), Monduzzi Editore 0: 17

CAZEMAJOR M., JOLY D. and MONTCHAMP-MOREAU C. 2000 Sex-ratio meiotic drive in Drosophila simulans is related to equational nondisjunction of the Y chromosome. Genetics 154(1): 229

JOLY D., BAZIN C., ZENG L.-W. and SING R.S. 1997 Genetic basis of sperm and testis length differences and epistatic effect on hybrid inviability and sperm motility between Drosophila simulans and Drosophila sechellia. Heredity 78(4): 354

JOLY D., BRESSAC C. and LACHAISE D. 1997 Gradually elongating testis and ‘sperm roller’ in Drosophila bifurca. Drosophila Information Service 80: 7

MONTCHAMP-MOREAU C. and JOLY D. 1997 Abnormal spermiogenesis is associated with the sex-ratio trait in Drosophila simulans. Heredity 79(1): 24

PAILLETTE M., BIZAT N. and JOLY D. 1997 Differentiation of dialects and courtship strategies in allopatric populations of Drosophila teissieri. J. Insect Physiol. 43(9): 809

BRESSAC C., JOLY D. and LACHAISE D. 1997 Huge spermatic diversity in Drosophila: sperm competition as a constraint in its evolution. Advances in Ethology suppl 32: 227

VIANEY-LIAUD M., JOLY D. and DUSSART G. 1996 Sperm competition in the simultaneous hermaphrodite freshwater snail Biomphalaria glabrata (Gastropoda: Pulmonata). J. Molluscan Studies 62(4): 449

BRESSAC C., FLEURY A., JOLY D. and LACHAISE D. 1995 The giant-sperm strategy: another way of being a male. The Journal of NIH Research 7: 53

JOLY D., BRESSAC, C. and LACHAISE, D 1995 Disentangling giant sperm. Nature 377(6546): 202

JOLY D. and BRESSAC C. 1994 Testis and receptacle lengths used as estimators of sperm length in the Drosophilidae family. Int. J. Insect Morphol. & Embryol. 23: 85

JOLY D. and LACHAISE D. 1994 Polymorphism in the sperm heteromorphic species of the Drosophila obscura group. J. Insect Physiol. 40(11): 933

JOLY, D. 1994 Number of spermatocytes per cyst in six species of the Drosophila melanogaster subgroup. Drosophila Information Service 75: 115

JOLY D. and LACHAISE D. 1993 Multiple mating frequency differs in two different geographic strains of D. teissieri. Drosophila Information Service 72: 126

BRESSAC C., JOLY D., DEVAUX J. and LACHAISE D. 1991 Can we predict the mating pattern of Drosophila females from the sperm length distribution in males? Experientia 47(1): 111

BRESSAC C., JOLY D., DEVAUX J., SERRES C., FENEUX D. and LACHAISE, D. 1991 Comparative kinetics of short and long sperm in sperm dimorphic Drosophila species. Cell Motility And The Cytoskeleton 19(4): 269 pdf

JOLY D., BRESSAC C, DEVAUX J. and LACHAISE D. 1991 Sperm length diversity in Drosophilidae Drosophila Information Service 70: 104

JOLY D., CARIOU M.-L. and LACHAISE D. 1991 Can sperm competition explain sperm polymorphism in Drosophila teissieri? Evolucion Biologica 5: 25

LACHAISE D., BRESSAC C. and JOLY D. 1991 Polymorphisme, Competition & Evolution des spermatozoïdes Pathologie Biologie (Editorial) 39(7): 654

JOLY D., BRESSAC C., SERRES C., FENEUX D. and FENEUX D. & LACHAISE D. 1991 Comparative kinetics of short and long sperm in sperm dimorphic Drosophila species. In Comparative Spermatology, 20 years after, B. Baccetti (ed.) Serono Symposia Publications from Raven Press, New York 75: 973

JOLY D., CARIOU M. L. and LACHAISE D. 1991 Can female polyandry explain within ejaculate sperm dimorphism? In Comparative Spermatology, 20 years after, B. Baccetti (ed.), Serono Symposia Publications from Raven Press, New York 75: 771

LACHAISE D. and JOLY D. 1991 Sperm and Evolution in Drosophila: morphological & molecular aspects. In Molecular Techniques in Taxonomy, G. Hewitt (ed.) Nato Asi Series Volume, Springer Verlag, Berlin. 0: 201

JOLY D., CARIOU M.-L, LACHAISE D. and DAVID J.R. 1989 Variation of sperm length and heteromorphism in drosophilid species Genet. Sel. Evol. 21(3): 283

CLOAREC A. and JOLY D. 1988 Choice of perch by the water stick insect. Behavioural Process 17(2): 131

JOLY D. and CLOAREC A 1988 The influence of light intensity on vertical distribution in Ranatra linearis L. (Heteroptera: Nepidae). J. Ethol. 6(2): 111

JOLY D. and LACHAISE D. 1988 Density of flies and male crowding affect the outcome of interspecific crosses between Drosophila simulans and D. mauritiana and the hybrid progeny number. Experientia 44(7): 0

JOLY, D. 1987 Between species divergence of cyst length distributions in the Drosophila melanogaster species complex. Jpn. J. Genet. 62(3): 257

Jonathan, Filée

Permanent Researcher (CR1), CNRS.
Equipe Elements Génétiques Mobiles (ELEGEM)

Tèl. 33 1 69 82 37 05
Fax 33 1 69 82 37 36


Evolutionnary genomics of Viruses and Transposons

Viruses are ubiquitous components of the biosphere and their number exceeds that of cells by at least an order of magnitude. This abundance is also accompanied by an extraordinary diversity in genome size, composition and organisation and viruses have been divided into many different classes based on these criteria. These observations raise multiple questions about the origin and evolution of different viral classes.

My researches focus on the diversity and genome evolution of various classes of mobile elements including large DNA viruses and phages, Retroviruses/Retrotransposons and DNA transposons. I’m also interested by the evolutionary relationships between these elements and their cellular hosts i.e. lateral gene exchange and exaptation of viral genes to accomplish cellular processes.

Curriculum vitae

2000 : DEA « Biodiversité : Génétique, Histoire et Mécanisme de l’évolution », Université Paris XI Orsay (France).
2000-2003 : PhD degree, Université Paris XI Orsay (France), IGM (Patrick Forterre Lab).
2003-2007 : Postdoc, Université Toulouse III (France), LMGM (Henry Krisch and Mick Chandler Labs).
2007- : Permanent Researcher (CR), CNRS, LEGS


Disdero, E. & J. Filée (2017) LoRTE: Detecting transposon-induced genomic variants using low coverage PacBio long read sequences. Mobile DNA, 8, 6. 10.1186/s13100-017-0088-x.

Filée J, Rouault JD, Harry M, Hua-Van A (2015) Mariner transposons are sailing in the genome of the blood-sucking bug Rhodnius prolixus. BMC genomics. 15;16(1):1061

Filée J (2015). Genomic comparison of closely related Giant Viruses supports an accordion-like model of evolution. Front Microbiol. 16;6:593

Filée J. (2014)  Multiple occurrences of Giant Virus core genes acquired by Eukaryotic genomes: the visible part of the iceberg ? Virology. ;466-467:53-9.

Kamoun C, Payen T, Hua-Van A, Filée J. (2013) Improving prokaryotic transposable elements identification using a combination of de novo and profile HMM methods. BMC Genomics 11;14:700

Filée J. (2013) Route of NCLDV evolution: the genomic accordion. Curr Opin Virol. 3(5):595-9

Metcalfe CJ, Filée J, Germon I, Joss J, Casane D. (2012) Mode and tempo in inflation of size of the Australian lungfish (Neoceratodus forsteri) genome: a major role for CR1-like elements. Mol. Biol. Evol. 9(11):3529-39

Hua-Van A, Le Rouzic A, Boutin TS, Filée J, Capy P. (2011) The struggle for life of the genome’s selfish architects. Biol. Direct 6:19..

Filée J, Chandler M. (2010) Gene exchange and the origin of Giant Viruses. Intervirology 53(5):354-61.

Rouault JD, Casse N, Chénais B, Hua-Van A, Filée J, Capy P (2009) Automatic classification within families of transposable elements: application to the mariner Family. Gene.15;448(2):227-32.

Filée J (2009) Lateral gene transfer, lineage-specific gene expansion and the evolution of Nucleo Cytoplasmic Large DNA viruses.J Invertebr Pathol. 101(3):169-71

Filée J, Pouget N, Chandler M. (2008) Phylogenetic evidence for extensive lateral acquisition of cellular genes by Nucleocytoplasmic Large DNA Viruses.BMC Evol Biol. 26;8:320

Filee J, Siguier P, Chandler M (2007) Insertion Sequence diversity in Archaea. Microbiol Mol Biol Rev. 71(1):121-57

Filee J, Siguier P, Chandler M (2007) I am what I eat and I eat what I am: acquisition of bacterial genes by Giant Viruses. Trends Genet. 23(1):10-5

Siguier P, Filee J, Chandler M (2006) Insertion Sequences in Prokaryotic Genomes. Curr. Opin. Microbiol. 9(5):526-31

Filee J, Bapteste E, Susko E, Krisch HM (2006) A Selective Barrier to Horizontal Gene Transfer in the T4-Type Bacteriophages that Has Preserved a Core Genome with the Viral Replication and Structural Genes. Mol. Biol. Evol. 23(9):1688-1696

Filee J, Comeau AM, Suttle CA, Krisch HM (2006) T4-type bacteriophages. Med Sci. 22(2):111-2.

Filee J, Tetart F, Suttle CA, Krisch HM (2005) Marine T4-type bacteriophages, a ubiquitous component of the dark Matter of the biosphere. Proc.Natl.Acad.Sci.USA. 102(35):12471-6

Filee J, Forterre P (2005) Viral proteins functioning in organelles: a cryptic origin? Trends Microbiol. 13(11):510-3

Filee J, Forterre P, Laurent J (2003) The role played by viruses on the Evolution of their cellular host: a view on informational proteins phylogenies. Res. Microbiol. 154:237-43

Myllykallio H, Leduc D, Filee J, Liebl U (2003) Life without dihydrofolate reductase FolA. Trends Microbiol. 11(5):220-3

Gadelle D, Filee J, Buhler C, Forterre P (2003) Phylogenomics of type II DNA topoisomerases. BioEssay 25: 232-242.

Myllykallio H, Lipowsky G, Leduc D, Filee J, Forterre P, Liebl U (2002) An alternative flavin-dependent mechanism for thymidylate synthesis. Science 5578:105-7.

Filee J, Forterre P, Sen-Lin T, Laurent J (2002) Evolution of DNA polymerase families: evidences for multiple gene exchange between cellular and viral proteins. J Mol Evol 54:763-73.